Beneficial effect of norepinephrine in the treatment of circulatory shock caused by tricyclic antidepressant overdose

Am J Emerg Med. 1988 Nov;6(6):566-8. doi: 10.1016/0735-6757(88)90092-7.


The beneficial effect of dopamine in circulatory shock induced by tricyclic antidepressants (TCA) overdose may be decreased due to compromise of the endogenous stores of norepinephrine caused by TCA. The successful outcome of two cases of TCA overdose complicated by hypotension, unresponsive to an initial treatment with physostigmine fluid challenge and dopamine (greater than 15 micrograms/kg/min) but subsequently responsive to an infusion of norepinephrine is reported.

Publication types

  • Case Reports

MeSH terms

  • Antidepressive Agents, Tricyclic / blood
  • Antidepressive Agents, Tricyclic / poisoning*
  • Dopamine / therapeutic use
  • Female
  • Hemodynamics / drug effects
  • Humans
  • Hypotension / chemically induced
  • Hypotension / drug therapy
  • Middle Aged
  • Norepinephrine / therapeutic use*
  • Shock / chemically induced
  • Shock / drug therapy*


  • Antidepressive Agents, Tricyclic
  • Dopamine
  • Norepinephrine