Association of IgG4-Related Arteritis With Recurrent Stroke

J Stroke Cerebrovasc Dis. 2020 Feb;29(2):104514. doi: 10.1016/j.jstrokecerebrovasdis.2019.104514. Epub 2019 Nov 30.


Immunoglobulin G4-related disease (IgG4)-related disease is a newly recognized form of immune-mediated disease, which is characterized by IgG4+ lymphoplasmacytic infiltration and fibrosis in the systemic organs. Although aortitis/periaortitis is a phenotype of IgG4-related disease, the relationship between cerebrovascular disease and IgG4-related disease remains unclear. Herein, we report the case of a 49-year-old man with recurrent stroke induced by IgG4-related arteritis. Case reports or studies examining the association between IgG4-related arteritis and stroke are limited. Although a definitive link between IgG4-related arteritis and stroke has not been established, IgG4-related arteritis should be considered as an etiology in patients with recurrent idiopathic stroke.

Keywords: Fluorodeoxyglucose PET; Idiopathic stroke; IgG4-related arteritis; IgG4-related disease; Recurrent stroke.

Publication types

  • Case Reports

MeSH terms

  • Arteritis / complications*
  • Arteritis / diagnosis
  • Arteritis / drug therapy
  • Arteritis / immunology
  • Glucocorticoids / therapeutic use
  • Humans
  • Immunoglobulin G / immunology*
  • Immunoglobulin G4-Related Disease / complications*
  • Immunoglobulin G4-Related Disease / diagnosis
  • Immunoglobulin G4-Related Disease / drug therapy
  • Immunoglobulin G4-Related Disease / immunology
  • Male
  • Middle Aged
  • Recurrence
  • Risk Factors
  • Stroke / diagnosis
  • Stroke / etiology*
  • Treatment Outcome


  • Glucocorticoids
  • Immunoglobulin G