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Associations Between Neighborhood Built Environment and Cognition Vary by Apolipoprotein E Genotype: Multi-Ethnic Study of Atherosclerosis

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Associations Between Neighborhood Built Environment and Cognition Vary by Apolipoprotein E Genotype: Multi-Ethnic Study of Atherosclerosis

Lilah Besser et al. Health Place.

Abstract

We examined whether neighborhood built environment (BE) and cognition associations in older adults vary by apolipoprotein E (APOE) genotype, a genetic risk factor for Alzheimer's disease (AD). We conducted a cross-sectional analysis of 4091 participants. Neighborhood characteristics included social and walking destination density (SDD, WDD), intersection density, and proportion of land dedicated to retail. Individuals were categorized as APOE ε2 (lower AD risk), APOE ε4 (higher AD risk), or APOE ε3 carriers. Among APOE ε2 carriers, greater proportion of land dedicated to retail was associated with better global cognition, and greater SDD, WDD, intersection density, and proportion of land dedicated to retail was associated with better processing speed. These associations were not observed in APOE ε3 or ε4 carriers. APOE ε2 carriers may be more susceptible to the potentially beneficial effects of denser neighborhood BEs on cognition; however, longitudinal studies are needed.

Keywords: Apolipoprotein E; Built environment; Cognition; Environment; Neighborhood; Older adults.

Conflict of interest statement

Conflict of interest and support:

Lilah Besser has no conflict of interest or funding to disclose.

James Galvin has no conflict of interest and is supported by NIA/NIH Grant R01 AG040211A1. Daniel Rodriguez has no conflict of interest or funding to disclose.

Teresa Seeman has no conflict of interest or funding to disclose.

Walter Kukull has no conflict of interest, and is supported by NIA/NIH Grant U01 AG016976.

Stephen Rapp has no conflicts of interest or funding to disclose Jennifer Smith has no conflict of interest or funding to disclose.

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