Association of rs4680 COMT, rs6280 DRD3, and rs7322347 5HT2A With Clinical Features of Youth-Onset Schizophrenia

Anna Morozova; Yana Zorkina; Konstantin Pavlov; Olga Pavlova; Zinaida Storozheva; Eugene Zubkov; Natalia Zakharova; Olga Karpenko; Alexander Reznik; Vladimir Chekhonin; Georgiy Kostyuk

doi:10.3389/fpsyt.2019.00830

Association of rs4680 COMT, rs6280 DRD3, and rs7322347 5HT2A With Clinical Features of Youth-Onset Schizophrenia

Front Psychiatry. 2019 Nov 12:10:830. doi: 10.3389/fpsyt.2019.00830. eCollection 2019.

Authors

Affiliations

¹ Department Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, Russia.
² N.A. Alekseev Psychiatric Clinical Hospital № 1, Moscow, Russia.
³ Department of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Moscow, Russia.

Abstract

We investigated the associations of rs4680 COMT, rs6280 DRD3, and rs7322347 5HT2A with youth-onset schizophrenia in the Russian population in a case-control study, and the role of the genotype in the severity of clinical features. The association between rs7322347 and schizophrenia (p = 0.0001) is described for the first time. Furthermore, we found a link with rs6280 and rs4680 in females (p = 0.001 and p = 0.02 respectively) and with rs7322347 in males (p = 0.002). Clinical symptoms were assessed on three scales: the Clinician-Rated Dimensions of Psychosis Symptom Severity scale, Positive and Negative Syndrome Scale, and Frontal Assessment Battery. Gender differences in clinical features are of particular interest. In our study we found gender differences in the severity of clinical features-higher scores for delusions (Positive and Negative Syndrome Scale and Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) in males and higher scores for depression, delusions, somatic concern, motor retardation, poor attention were found in females.

Keywords: 5-hydroxytryptamine 2A receptors; catechol-O-methyltransferase; dopamine receptor D3; schizophrenia; single-nucleotide polymorphism; youth-onset.