Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer

Cancer. 1988 Dec 1;62(11):2297-300. doi: 10.1002/1097-0142(19881201)62:11<2297::aid-cncr2820621106>;2-7.


Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Ammonia-Lyases / blood*
  • Breast Neoplasms / enzymology
  • Female
  • Gastrointestinal Neoplasms / enzymology
  • Humans
  • Hydroxymethylbilane Synthase / blood*
  • Leukocytes, Mononuclear / enzymology*
  • Lung Neoplasms / enzymology
  • Male
  • Middle Aged
  • Neoplasm Metastasis / enzymology*
  • Ovarian Neoplasms / enzymology


  • Hydroxymethylbilane Synthase
  • Ammonia-Lyases