Medicinal Cannabis in Orthopaedic Practice

J Am Acad Orthop Surg. 2020 Apr 1;28(7):268-277. doi: 10.5435/JAAOS-D-19-00438.


Cannabis has gained widespread public advocacy since its legalization in several states with recent evidence suggesting that its self-reported use has increased in patients undergoing a primary total joint arthroplasty. The endocannabinoid system has been proposed to play a role in decreasing the inflammatory cascade and enhancing pain management. For these reasons, interest has emerged in the orthopaedic community as a potential treatment or adjunct to treatment in many musculoskeletal conditions. However, the evidence to date is scant and precludes recommendations for its widespread use. Given the current paucity of evidence in the orthopaedic cohort, future research is warranted in this area to determine the efficacy and safety before endorsements can be made by orthopaedic surgeons.

Publication types

  • Review

MeSH terms

  • Arthroplasty*
  • Drug Utilization / statistics & numerical data*
  • Humans
  • Medical Marijuana / adverse effects
  • Medical Marijuana / therapeutic use*
  • Musculoskeletal Diseases / drug therapy
  • Pain Management / methods*
  • United States


  • Medical Marijuana