Sorting mtDNA Species-the Role of nDNA-mtDNA Co-evolution

Cell Metab. 2019 Dec 3;30(6):1002-1004. doi: 10.1016/j.cmet.2019.11.005.


The segregation of heteroplasmic mtDNA species was thought to be mostly stochastic. However, recent findings, including a study by Latorre-Pellicer et al. (2019) published in this issue of Cell Metabolism, provide evidence that nuclear DNA and mitochondrial DNA interactions play an important role in the sorting process.

Publication types

  • Comment

MeSH terms

  • DNA, Mitochondrial*
  • Female
  • Humans
  • Mitochondria
  • Mothers*


  • DNA, Mitochondrial