Oral phospholipidic curcumin in juvenile idiopathic arthritis-associated uveitis

Eur J Ophthalmol. 2020 Nov;30(6):1390-1396. doi: 10.1177/1120672119892804. Epub 2019 Dec 4.


Purpose: To evaluate the efficacy and the safety of curcumin-phosphatidylcholine complex in children affected by juvenile idiopathic arthritis-associated uveitis as an adjunctive treatment to chronic systemic immunosuppressive therapy.

Methods: In this retrospective, longitudinal study, we treated patients affected by juvenile idiopathic arthritis-associated uveitis with residual low-grade inflammatory activity in the anterior chamber with one tablet of curcumin-phosphatidylcholine complex per day, over a year. Low-grade inflammatory activity was characterized by flare 1+ at slit-lamp examination and 10-50 photon counts per ms) at the FC500 laser flare meter. Inactivity of uveitis was defined as complete disappearance of flare at the slit-lamp examination and values <10 ph/ms at laser flare meter. Conversely, recurrence of the uveitis was defined as a one-step increase from baseline in anterior chamber cells levels or laser flare meter measurements >50 ph/ms.

Results: A total of 22 out of 27 patients (81%) achieved inactivity at the end of the study. Five patients (19%) did not show a significant reduction in anterior chamber flare, remaining stable throughout the follow-up. Only three episodes of flare-ups in three different patients were recorded. Overall, the treatment was well tolerated by all patients and no ocular discomfort, ocular side effects, or allergic reactions were registered.

Conclusion: Adjunctive therapy with curcumin in patients affected by juvenile idiopathic arthritis-associated uveitis improves mild chronic anterior chamber flare and presents a good safety profile. Despite being mild, anterior chamber inflammation should be minimized to avoid the development of sight-threatening complications in these patients.

Keywords: Anterior chamber inflammation; curcumin; juvenile idiopathic arthritis; laser flare meter; pediatric uveitis.

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Arthritis, Juvenile / complications*
  • Arthritis, Juvenile / drug therapy
  • Child
  • Child, Preschool
  • Curcumin / administration & dosage*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Retrospective Studies
  • Treatment Outcome
  • Uveitis / drug therapy*
  • Uveitis / etiology
  • Young Adult


  • Anti-Inflammatory Agents, Non-Steroidal
  • Curcumin