The m 6 A epitranscriptome: transcriptome plasticity in brain development and function

Nat Rev Neurosci. 2020 Jan;21(1):36-51. doi: 10.1038/s41583-019-0244-z. Epub 2019 Dec 5.

Abstract

The field of epitranscriptomics examines the recently deciphered form of gene expression regulation that is mediated by type- and site-specific RNA modifications. Similarly to the role played by epigenetic mechanisms - which operate via DNA and histone modifications - epitranscriptomic modifications are involved in the control of the delicate gene expression patterns that are needed for the development and activity of the nervous system and are essential for basic and higher brain functions. Here we describe the mechanisms that are involved in the writing, erasing and reading of N6-methyladenosine, the most prevalent internal mRNA modification, and the emerging roles played by N6-methyladenosine in the nervous system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine / analogs & derivatives
  • Adenosine / physiology
  • Animals
  • Axon Guidance
  • Brain / embryology*
  • Epigenesis, Genetic / physiology*
  • Gene Expression Regulation*
  • Humans
  • Neurogenesis
  • Neuroglia / physiology
  • RNA, Messenger / physiology
  • Transcriptome*

Substances

  • RNA, Messenger
  • N(6)-methyladenosine
  • Adenosine