TREK for High-Speed and High-Frequency Conduction through the Axon

Neuron. 2019 Dec 4;104(5):831-833. doi: 10.1016/j.neuron.2019.11.015.


In this issue of Neuron, Kanda et al. (2019) find that the two-pore domain potassium channels TRAAK and TREK1 drive axonal action potential repolarization for high-speed and high-frequency nervous impulses in mammalian myelinated nerves.

Publication types

  • Comment

MeSH terms

  • Action Potentials
  • Animals
  • Axons
  • Potassium Channels, Tandem Pore Domain*
  • Ranvier's Nodes*


  • Potassium Channels, Tandem Pore Domain
  • potassium channel protein TREK-1