Effects of Fish Oil Supplement on Psoriasis: A Meta-Analysis of Randomized Controlled Trials

BMC Complement Altern Med. 2019 Dec 5;19(1):354. doi: 10.1186/s12906-019-2777-0.

Abstract

Background: Fish oils, which contain omega-3 polyunsaturated fatty acids as the active ingredients, possess anti-inflammatory activities and may have therapeutic potential in diseases with an inflammatory etiology. Fish oil supplement has been advocated for treating psoriasis which is a chronic inflammatory dermatosis.

Objective: We aimed to investigate the effects of fish oil supplement on psoriasis.

Methods: We searched CENTRAL, Embase and MEDLINE on 24 January 2018 for randomized control trials (RCTs) on the effects of fish oil supplement in treating psoriasis. The Cochrane Collaboration's tool was used to assess the risk of bias of included RCTs. We performed a random-effects model meta-analysis to obtain the pooled treatment effect estimates.

Results: We included 13 RCTs with 625 participants. Three RCTs involving 337 participants provided usable data for meta-analysis. Fish oil supplement did not significantly reduce the severity of psoriasis when assessed by Psoriasis Area and Severity Index score (mean difference - 0.28; 95% confidence interval - 1.74 to 1.19).

Conclusion: The current evidence does not support the use of fish oil supplement in treating psoriasis.

Keywords: Fish oil; Meta-analysis; Polyunsaturated fatty acids; Psoriasis; Systematic review.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Dietary Supplements*
  • Fatty Acids, Omega-3
  • Fish Oils / therapeutic use*
  • Humans
  • Psoriasis / diet therapy*
  • Randomized Controlled Trials as Topic

Substances

  • Fatty Acids, Omega-3
  • Fish Oils