No genetic evidence for involvement of alcohol dehydrogenase genes in risk for Parkinson's disease

Neurobiol Aging. 2020 Mar;87:140.e19-140.e22. doi: 10.1016/j.neurobiolaging.2019.11.006. Epub 2019 Nov 14.

Abstract

Multiple genes have been implicated in Parkinson's disease (PD), including causal gene variants and risk variants typically identified using genome-wide association studies. Variants in the alcohol dehydrogenase genes ADH1C and ADH1B are among the genes that have been associated with PD, suggesting that this family of genes may be important in PD. As part of the International Parkinson's Disease Genomics Consortium's efforts to scrutinize previously reported risk factors for PD, we explored genetic variation in the alcohol dehydrogenase genes ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, and ADH7 using imputed genome-wide association study data from 15,097 cases and 17,337 healthy controls. Rare-variant association tests and single-variant score tests did not show any statistically significant association of alcohol dehydrogenase genetic variation with the risk for PD.

Keywords: ADH1C; Alcohol dehydrogenase; Burden tests; Genetics; Parkinson's disease; Risk.

Publication types

  • Case Reports
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alcohol Dehydrogenase / genetics*
  • Genetic Variation
  • Genome-Wide Association Study*
  • Negative Results*
  • Parkinson Disease / genetics*
  • Risk

Substances

  • ADH1B protein, human
  • ADH1C protein, human
  • Alcohol Dehydrogenase