Peripheral Nerve Diffusion Tensor Imaging : Interreader and Test-retest Reliability as Quantified by the Standard Error of Measurement

doi:10.1007/s00062-019-00859-0

. 2020 Dec;30(4):679-689.

doi: 10.1007/s00062-019-00859-0. Epub 2019 Dec 5.

Peripheral Nerve Diffusion Tensor Imaging : Interreader and Test-retest Reliability as Quantified by the Standard Error of Measurement

Fabian Preisner¹, Philipp Bäumer^{1

2}, Michaela Wehrstein³, Birgit Friedmann-Bette³, Matthes Hackbusch⁴, Sabine Heiland¹, Martin Bendszus¹, Moritz Kronlage⁵

Affiliations

¹ Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
² Center for Radiology Dia.log, Vinzenz-von-Paul Str. 8, 84503, Altötting, Germany.
³ Department of Sports Medicine (Internal Medicine VII), Medical Clinic, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
⁴ Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 130.3, 69120, Heidelberg, Germany.
⁵ Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. Moritz.Kronlage@med.uni-heidelberg.de.

PMID: 31807812
DOI: 10.1007/s00062-019-00859-0

Peripheral Nerve Diffusion Tensor Imaging : Interreader and Test-retest Reliability as Quantified by the Standard Error of Measurement

Fabian Preisner et al. Clin Neuroradiol. 2020 Dec.

. 2020 Dec;30(4):679-689.

doi: 10.1007/s00062-019-00859-0. Epub 2019 Dec 5.

Authors

Fabian Preisner¹, Philipp Bäumer^{1

2}, Michaela Wehrstein³, Birgit Friedmann-Bette³, Matthes Hackbusch⁴, Sabine Heiland¹, Martin Bendszus¹, Moritz Kronlage⁵

Affiliations

¹ Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
² Center for Radiology Dia.log, Vinzenz-von-Paul Str. 8, 84503, Altötting, Germany.
³ Department of Sports Medicine (Internal Medicine VII), Medical Clinic, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
⁴ Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 130.3, 69120, Heidelberg, Germany.
⁵ Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. Moritz.Kronlage@med.uni-heidelberg.de.

PMID: 31807812
DOI: 10.1007/s00062-019-00859-0

Abstract

Purpose: Diffusion tensor imaging (DTI) is increasingly being used in magnetic resonance neurography (MRN). The purpose of this study was to determine the interreader and test-retest reliability of peripheral nerve DTI in MRN with focus on the sciatic nerve.

Methods: In this prospective study 27 healthy volunteers each underwent 3 scans of a short DTI protocol on separate days consisting of a T2-weighted turbo spin-echo and single-shot DTI sequence of the sciatic nerve of the dominant leg. The DTI parameters fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were obtained after manual nerve segmentation by two independent readers. Intraclass correlation coefficients (ICC), standard error of measurement (SEM), and Bland-Altman plots were calculated as measures for both interreader and test-retest agreement for all readout parameters.

Results: The mean ± standard deviation was 0.507 ± 0.05 for FA, 1308.5 ± 162.4 × 10^-6 mm²/s for MD, 905.6 ± 145.4 ×10^-6 mm²/s for RD and 2114.1 ± 219.2 × 10^-6 mm²/s for AD. The SEM for FA was 0.02 for interreader and test-retest agreement, the SEM for MD, RD, and AD ranged between 46.2 × 10^-6 mm²/s (RD) and 70.1 × 10^-6 mm²/s (AD) for interreader reliability and between 45.9 × 10^-6 mm²/s (RD) and 70.1 × 10^-6 mm²/s (AD) for test-retest reliability. The ICC for interreader reliability of DTI parameters ranged between 0.81 and 0.92 and ICC for test-retest reliability between 0.76 and 0.91.

Conclusion: Peripheral nerve DTI of the sciatic nerve is reliable and reproducible. The measures presented here may serve as first orientation values of measurement accuracy when interpreting parameters of sciatic nerve DTI.

Keywords: Diffusion tensor imaging; Magnetic resonance imaging; Peripheral nervous system; Reference values; Reproducibility of results.

PubMed Disclaimer

Cited by

Feasibility of in vivo multi-parametric quantitative magnetic resonance imaging of the healthy sciatic nerve with a unified signal readout protocol.
Boonsuth R, Battiston M, Grussu F, Samlidou CM, Calvi A, Samson RS, Gandini Wheeler-Kingshott CAM, Yiannakas MC. Boonsuth R, et al. Sci Rep. 2023 Apr 21;13(1):6565. doi: 10.1038/s41598-023-33618-w. Sci Rep. 2023. PMID: 37085693 Free PMC article.
Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis.
Foesleitner O, Knop KC, Lindenau M, Preisner F, Bäumer P, Heiland S, Bendszus M, Kronlage M. Foesleitner O, et al. Diagnostics (Basel). 2023 Mar 25;13(7):1237. doi: 10.3390/diagnostics13071237. Diagnostics (Basel). 2023. PMID: 37046455 Free PMC article.
Sciatic nerve fractional anisotropy and neurofilament light chain protein are related to sensorimotor deficit of the upper and lower limbs in patients with type 2 diabetes.
Kender Z, Jende JME, Kurz FT, Tsilingiris D, Schimpfle L, Sulaj A, von Rauchhaupt E, Bartl H, Mooshage C, Göpfert J, Nawroth P, Herzig S, Szendroedi J, Bendszus M, Kopf S. Kender Z, et al. Front Endocrinol (Lausanne). 2023 Mar 14;14:1046690. doi: 10.3389/fendo.2023.1046690. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37008917 Free PMC article.
Quantitative MR-Neurography at 3.0T: Inter-Scanner Reproducibility.
Preisner F, Behnisch R, Schwehr V, Godel T, Schwarz D, Foesleitner O, Bäumer P, Heiland S, Bendszus M, Kronlage M. Preisner F, et al. Front Neurosci. 2022 Feb 16;16:817316. doi: 10.3389/fnins.2022.817316. eCollection 2022. Front Neurosci. 2022. PMID: 35250457 Free PMC article.
Reliability and reproducibility of sciatic nerve magnetization transfer imaging and T2 relaxometry.
Preisner F, Behnisch R, Foesleitner O, Schwarz D, Wehrstein M, Meredig H, Friedmann-Bette B, Heiland S, Bendszus M, Kronlage M. Preisner F, et al. Eur Radiol. 2021 Dec;31(12):9120-9130. doi: 10.1007/s00330-021-08072-9. Epub 2021 Jun 9. Eur Radiol. 2021. PMID: 34104997 Free PMC article.

References

1. Hagmann P, Jonasson L, Maeder P, Thiran JP, Wedeen VJ, Meuli R. Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond. Radiographics. 2006;26(Suppl 1):S205–23. - DOI
1. Mori S, Zhang J. Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron. 2006;51:527–39. - DOI - PubMed - PMC
1. Kronlage M, Pitarokoili K, Schwarz D, Godel T, Heiland S, Yoon MS, Bendszus M, Bäumer P. Diffusion tensor imaging in chronic inflammatory demyelinating polyneuropathy: diagnostic accuracy and correlation with electrophysiology. Invest Radiol. 2017;52:701–7. - DOI
1. Haakma W, Jongbloed BA, Froeling M, Goedee HS, Bos C, Leemans A, van den Berg LH, Hendrikse J, van der Pol WL. MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy. Eur Radiol. 2017;27:2216–24. - DOI - PubMed - PMC
1. Vaeggemose M, Pham M, Ringgaard S, Tankisi H, Ejskjaer N, Heiland S, Poulsen PL, Andersen H. Magnetic resonance neurography visualizes abnormalities in sciatic and tibial nerves in patients with type 1 diabetes and neuropathy. Diabetes. 2017;66:1779–88. https://doi.org/10.2337/db16-1049 - DOI - PubMed - PMC

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer
Miscellaneous
- NCI CPTAC Assay Portal

[1] Hagmann P, Jonasson L, Maeder P, Thiran JP, Wedeen VJ, Meuli R. Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond. Radiographics. 2006;26(Suppl 1):S205–23. - DOI

[2] Hagmann P, Jonasson L, Maeder P, Thiran JP, Wedeen VJ, Meuli R. Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond. Radiographics. 2006;26(Suppl 1):S205–23. - DOI

[3] Mori S, Zhang J. Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron. 2006;51:527–39. - DOI - PubMed - PMC

[4] Mori S, Zhang J. Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron. 2006;51:527–39. - DOI - PubMed - PMC

[5] Kronlage M, Pitarokoili K, Schwarz D, Godel T, Heiland S, Yoon MS, Bendszus M, Bäumer P. Diffusion tensor imaging in chronic inflammatory demyelinating polyneuropathy: diagnostic accuracy and correlation with electrophysiology. Invest Radiol. 2017;52:701–7. - DOI

[6] Kronlage M, Pitarokoili K, Schwarz D, Godel T, Heiland S, Yoon MS, Bendszus M, Bäumer P. Diffusion tensor imaging in chronic inflammatory demyelinating polyneuropathy: diagnostic accuracy and correlation with electrophysiology. Invest Radiol. 2017;52:701–7. - DOI

[7] Haakma W, Jongbloed BA, Froeling M, Goedee HS, Bos C, Leemans A, van den Berg LH, Hendrikse J, van der Pol WL. MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy. Eur Radiol. 2017;27:2216–24. - DOI - PubMed - PMC

[8] Haakma W, Jongbloed BA, Froeling M, Goedee HS, Bos C, Leemans A, van den Berg LH, Hendrikse J, van der Pol WL. MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy. Eur Radiol. 2017;27:2216–24. - DOI - PubMed - PMC

[9] Vaeggemose M, Pham M, Ringgaard S, Tankisi H, Ejskjaer N, Heiland S, Poulsen PL, Andersen H. Magnetic resonance neurography visualizes abnormalities in sciatic and tibial nerves in patients with type 1 diabetes and neuropathy. Diabetes. 2017;66:1779–88. https://doi.org/10.2337/db16-1049 - DOI - PubMed - PMC

[10] Vaeggemose M, Pham M, Ringgaard S, Tankisi H, Ejskjaer N, Heiland S, Poulsen PL, Andersen H. Magnetic resonance neurography visualizes abnormalities in sciatic and tibial nerves in patients with type 1 diabetes and neuropathy. Diabetes. 2017;66:1779–88. https://doi.org/10.2337/db16-1049 - DOI - PubMed - PMC

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Peripheral Nerve Diffusion Tensor Imaging : Interreader and Test-retest Reliability as Quantified by the Standard Error of Measurement

Affiliations

Peripheral Nerve Diffusion Tensor Imaging : Interreader and Test-retest Reliability as Quantified by the Standard Error of Measurement

Authors

Affiliations

Abstract

Similar articles

Cited by

References

MeSH terms

LinkOut - more resources

Full Text Sources

Miscellaneous