Fly model sheds light on brain disease

Elife. 2019 Dec 6;8:e53233. doi: 10.7554/eLife.53233.

Abstract

Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPɑ contributes to the progressive brain disease CLN4.

Keywords: D. melanogaster; cysteine-string protein; lysosome; neurodegeneration; neuronal ceroid lipofuscinosis; neuroscience.

Publication types

  • Comment

MeSH terms

  • Animals
  • Brain Diseases*
  • Diptera*
  • Humans
  • Neuronal Ceroid-Lipofuscinoses*