Fly model sheds light on brain disease

Elife. 2019 Dec 6;8:e53233. doi: 10.7554/eLife.53233.

Authors

Martin H Berryer^{1

2}, Sara G Kosmaczewski^{1

2}, Lindy E Barrett^{1

2}

Affiliations

¹ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States.
² Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, United States.

Abstract

Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPɑ contributes to the progressive brain disease CLN4.

Keywords: D. melanogaster; cysteine-string protein; lysosome; neurodegeneration; neuronal ceroid lipofuscinosis; neuroscience.

© 2019, Berryer et al.

Publication types

Comment

MeSH terms

Animals
Brain Diseases*
Diptera*
Humans
Neuronal Ceroid-Lipofuscinoses*