Efficacy of low-level laser therapy associated with fluoride therapy for the desensitisation of molar-incisor hypomineralisation: Randomised clinical trial

Int J Paediatr Dent. 2020 May;30(3):323-333. doi: 10.1111/ipd.12602. Epub 2019 Dec 23.


Background: Molar-incisor hypomineralisation (MIH) is a qualitative enamel defect.

Aim: To investigate the low-level laser therapy (LLLT) associated with fluoride varnish for the desensitisation of teeth with MIH.

Design: A randomised clinical trial was conducted with 66 children, randomly allocated to the treatments: laser (L); fluoride varnish (FV); and laser + fluoride varnish (L + FV). The participants in the L group underwent two sessions of LLLT (48-hour interval). The FV group received four applications of varnish at one-week intervals. The L + FV underwent two sessions of LLLT and four applications of varnish. Prior to each session and one month after the onset of treatment, tooth sensitivity and its magnitude were evaluated. Intra- and inter-group comparisons were performed (α = 5%).

Results: A significant reduction in the mean sensitivity score was found over time in all groups. After the final treatment, a significant difference was found between the L and L + FV groups (P = .011), with a lower score in the L + FV group (0.09), whereas no difference was found between the FV and L + FV groups (P = .095).

Conclusions: Fluoride varnish and the combination of treatments (L + FV) had greater desensitising action on teeth with MIH. Laser therapy demonstrated an immediate desensitising effect, whereas fluoride varnish had a late-onset effect.

Keywords: child; dentine sensitivity; fluoride, topical; low-level laser light therapy; tooth demineralisation.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Cariostatic Agents
  • Child
  • Fluorides*
  • Fluorides, Topical
  • Humans
  • Incisor
  • Low-Level Light Therapy*
  • Molar


  • Cariostatic Agents
  • Fluorides, Topical
  • Fluorides