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, 2019 (1), 415-420

Improvements in Diagnosis and Risk Assessment of Primary and Secondary Antiphospholipid Syndrome

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Improvements in Diagnosis and Risk Assessment of Primary and Secondary Antiphospholipid Syndrome

Michelle Petri. Hematology Am Soc Hematol Educ Program.

Abstract

Classification criteria for antiphospholipid syndrome have not been updated since the revised Sapporo classification criteria were published in 2006. These criteria have limitations in that they omit nonclassical manifestations (hematologic and neurologic), include anticardiolipin and anti-β2-glycoprotein I immunoglobulin (Ig)M isotypes, and do not separately consider primary (no autoimmune disease) or secondary (usually systemic lupus erythematosus) disease. Recent findings in antiphospholipid antibody include fluctuation of antiphospholipid antibodies, recognition that IgA isotypes do confer risk, identification of the role of complementopathy in catastrophic antiphospholipid syndrome, and elucidation of the role of thrombosis risk equations.

Conflict of interest statement

Conflict-of-interest disclosure: M.P. is a consultant to and receives grant support from Exagen Inc.

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