Mutualism in the Marrow

John P Chute; Christina M Termini

doi:10.1016/j.stem.2019.11.007

Mutualism in the Marrow

Cell Stem Cell. 2019 Dec 5;25(6):731-733. doi: 10.1016/j.stem.2019.11.007.

Authors

John P Chute¹, Christina M Termini²

Affiliations

¹ Division of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA, USA; Eli and Edythe Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA. Electronic address: jchute@mednet.ucla.edu.
² Division of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA, USA.

PMID: 31809734
DOI: 10.1016/j.stem.2019.11.007

Abstract

Cross-talk between hematopoietic stem cells (HSCs) and the HSC niche is likely important in hematopoiesis but not well demonstrated. Now in Cell Stem Cell, Chen et al. (2019) describe how specialized endothelial cells regulate hematopoietic stem cell maintenance and how hematopoietic stem/progenitor cells facilitate vascular regeneration in return.

Publication types

Comment

MeSH terms

Apelin
Bone Marrow*
Endothelial Cells
Hematopoiesis
Stem Cell Niche*
Symbiosis

Substances

Apelin