Association of LEP-rs7799039 and ADIPOQ-rs2241766 polymorphisms with sleep duration in preschool age children

Sleep Med. 2020 Feb:66:68-75. doi: 10.1016/j.sleep.2019.07.028. Epub 2019 Aug 15.


Objectives: To evaluate the association of leptin rs7799039 and adiponectin rs2241766 gene polymorphisms on daily sleep duration in 4-5-year-old children.

Methods: Data were obtained from the Predictors of Maternal and Infant Excess Body Weight - PREDI Study, a cohort study conducted in Joinville - Brazil. The current study is a cross-sectional study, which was carried out in the homes of the participants between July 2016 and August 2017. Total sleep time was self-reported by the mothers. The average total sleep time was classified according to the recommendation of the National Sleep Foundation for children aged 3-5 years: ≥10 or <10 h of sleep/day. Genotyping analysis was performed in blood samples by the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) technique.

Results: Of the 216 children included in the study, 167 (77.3%) and 49 (22.7%) had ≥10 and <10 h of sleep/day, respectively. There was a significant decrease in the average total sleep time as the number of risk alleles of the two polymorphisms increased (LEP: GG = 11 h18, GA = 10 h42, AA = 10 h15; ADIPOQ: TT = 11 h00, TG + GG = 10 h28). Interaction analysis showed a progressive increase in the odds of children sleeping <10 h/day at preschool age with an increasing number of risk alleles of the LEP and ADIPOQ polymorphisms (OR = 7.44, 95%CI, 2.45-22.55).

Conclusions: We found a progressive increase in the odds of 4-5 year old children sleeping less than 10 h/day as the number of risk alleles of the LEP-rs7799039 and ADIPOQ-rs2241766 polymorphisms increased, even after adjustment for other maternal and child characteristics.

Keywords: Adiponectin; Leptin; Polymorphism; Preschooler; Sleep deprivation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / genetics*
  • Alleles*
  • Brazil
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Leptin / genetics*
  • Male
  • Polymorphism, Single Nucleotide / genetics*
  • Sleep / physiology*
  • Time Factors


  • ADIPOQ protein, human
  • Adiponectin
  • LEP protein, human
  • Leptin