Ménage à trois: regulation of host immunity by enteric neuro-immune-microbiota cross talks

Curr Opin Neurobiol. 2020 Jun;62:26-33. doi: 10.1016/j.conb.2019.10.006. Epub 2019 Dec 4.


Over the past decade, our understanding of intestinal immunology has been transformed by the realization that the gut microbiota shapes immune development, function and disease susceptibility. Strikingly, the enteric nervous system is now emerging as a cellular hub that sense microbiota-derived signals and rapidly orchestrate immunological outcomes. Here, I discuss recent advances in our understanding of intestinal neuroimmune communications, their modulation by the gut microbiota, and the consequent impact on host immunity, in health and disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Enteric Nervous System*
  • Gastrointestinal Microbiome*
  • Immunity, Innate
  • Intestines