Recreating, expanding and using nephron progenitor populations

Melissa H Little; Kynan T Lawlor

doi:10.1038/s41581-019-0238-0

Recreating, expanding and using nephron progenitor populations

Nat Rev Nephrol. 2020 Feb;16(2):75-76. doi: 10.1038/s41581-019-0238-0.

Authors

Melissa H Little^{1

2

3}, Kynan T Lawlor⁴

Affiliations

¹ Murdoch Children's Research Institute, Parkville, VIC, Australia. melissa.little@mcri.edu.au.
² Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia. melissa.little@mcri.edu.au.
³ Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, VIC, Australia. melissa.little@mcri.edu.au.
⁴ Murdoch Children's Research Institute, Parkville, VIC, Australia.

Abstract

2019 saw advances in the generation of induced pluripotent stem cell (iPSC)-derived nephron progenitors and in our understanding of how nephrons form in a kidney organoid. Fundamental studies of regeneration in zebra fish continue to provide vital clues as to how we might use iPSC-derived cells to regenerate a human nephron in vivo.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation / physiology*
Humans
Induced Pluripotent Stem Cells / cytology
Induced Pluripotent Stem Cells / physiology*
Nephrons / embryology*
Nephrons / physiology
Organogenesis / physiology*
Organoids
Regeneration / physiology*
Stem Cells
Zebrafish

Abstract

Publication types

MeSH terms

Grants and funding