TCGA Molecular Subgroups in Endometrial Undifferentiated/Dedifferentiated Carcinoma

Pathol Oncol Res. 2020 Jul;26(3):1411-1416. doi: 10.1007/s12253-019-00784-0. Epub 2019 Dec 6.


We aimed to classify undifferentiated/dedifferentiated carcinoma (UDC/DDC) according to the four TCGA molecular subgroups of endometrial cancer: microsatellite-instable/hypermutated (MSI), POLE-mutant/ultramutated (POLE), copy-number-low/p53-wild-type (p53wt), and copy-number-high/p53-abnormal (p53abn), through a systematic review and meta-analysis. Electronic databases were searched from January 2013 to July 2019 for studies assessing the TCGA classification in endometrial UDC/DDC series. Pooled prevalence of each TCGA subgroup on the total UDC/DDCs was calculated. Three studies with 73 patients were included. Pooled prevalence of the TCGA subgroups were: 12.4% for the POLE subgroup, 44% for the MSI subgroup, 18.6% for the p53abn subgroup, 25% for the p53wt group. All TCGA groups are represented in UDC/DDC, with a predominance of the MSI group, indicating a biological heterogeneity. Hypermutated/ultramutated cancers constitute the majority of UDC/DDC, suggesting a crucial difference with other high-risk histologies of endometrial carcinoma.

Keywords: Cancer; Endometrium; PROMISE; Risk assessment; Treatment.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Endometrial Neoplasms / classification*
  • Endometrial Neoplasms / genetics*
  • Female
  • Gene Dosage
  • Humans
  • Mutation
  • Transcriptome