Effect of two different dietary fatty acid profiles and variant rs266729 in ADIPOQ on weight loss and adiponectin concentrations

Endocrinol Diabetes Nutr (Engl Ed). 2020 Jun-Jul;67(6):374-382. doi: 10.1016/j.endinu.2019.09.004. Epub 2019 Dec 4.
[Article in English, Spanish]


Background: The role of ADIPOQ gene rs266729 variants on weight loss after a dietary intervention are still unclear.

Objective: To analyze the effects of the ADIPOQ gene rs266729 variant n weight loss, cardiovascular risk factors, and adiponectin levels after two hypocaloric diets with different dietary fatty profiles.

Design: A population of 362 obese patients was enrolled in a randomized clinical trial with two diets (Diet M, monounsaturated fat-enriched diet, and Diet P, polyunsaturated-fat enriched diet). Anthropometric measurements, an assessment of nutritional intake, and biochemical tests were performed at baseline and after 12 weeks.

Results: Weight loss was similar with both diets. After Diet M, only subjects with CC genotype showed significant improvements in total cholesterol (CC vs. CG±GG) (-9.0±1.1mU/L vs. -4.5±2.4mg/dL, p=0.01), LDL cholesterol (-6.0±1.1mg/dL vs. -3.0±0.9mg/dL, p=0.03), glucose (-4.7±1.1mg/dL vs. -0.6±0.5mg/dL, p=0.01), and insulin levels (-2.6±1.0mU/L vs. -0.7±0.3mU/L, p=0.02) and in HOMA-IR (-0.5±0.2 units vs. -0.2±0.4 units, p=0.03). The same improvement was reported after Diet P in all parameters, including total cholesterol (CC vs. CG±GG) (-8.0±1.2mU/L vs. -2.1±1.4mg/dL, p=0.02), LDL cholesterol (-7.3±1.2mg/dL vs. -2.1±0.8mg/dL, p=0.02), glucose (-3.2±0.1mg/dL vs. -0.2±0.5mg/dL, p=0.01), and insulin levels (-2.5±1.0mU/L vs. -1±0.6mU/L, p=0.02) and HOMA-IR (-0.5±0.1 units vs. -0.3±0.4 units, p=0.02). Only subjects with CC genotype showed significant increases in adiponectin levels after both diets: (Diet M: 10.3±2.0ng/dL vs. Diet P: 9.3±2.9ng/dL, p=0.43).

Conclusion: The CC genotype of ADIPOQ gene rs266729 variant is associated to increased adiponectin levels and decreases in LDL cholesterol, glucose, insulin, and HOMA-IR levels after weight loss.

Keywords: Adiponectin gene; Cardiovascular risk factors; Dietary fatty acids; Factores de riesgo cardiovascular; Gen de adiponectina; rs266729; Ácidos grasos en la dieta.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adiponectin / blood*
  • Adiponectin / genetics
  • Adult
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / etiology
  • Diet, Reducing*
  • Fatty Acids, Monounsaturated / administration & dosage*
  • Fatty Acids, Unsaturated / administration & dosage*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obesity / blood*
  • Obesity / complications
  • Obesity / genetics*
  • Prospective Studies
  • Risk Factors
  • Weight Loss / genetics*


  • ADIPOQ protein, human
  • Adiponectin
  • Fatty Acids, Monounsaturated
  • Fatty Acids, Unsaturated