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, 50 (3), 935-948

Influence of a Combined Gluten-Free and Casein-Free Diet on Behavior Disorders in Children and Adolescents Diagnosed With Autism Spectrum Disorder: A 12-Month Follow-Up Clinical Trial

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Influence of a Combined Gluten-Free and Casein-Free Diet on Behavior Disorders in Children and Adolescents Diagnosed With Autism Spectrum Disorder: A 12-Month Follow-Up Clinical Trial

Pablo José González-Domenech et al. J Autism Dev Disord.

Abstract

The use of alternative interventions, such as gluten-free and casein-free (GFCF) diets, is frequent due to limited therapies for Autism Spectrum Disorder (ASD). Our aims were to determine the influence of a GFCF diet on behavior disorders in children and adolescents diagnosed with ASD and the potential association with urinary beta-casomorphin concentrations. Thirty-seven patients were recruited for this crossover trial. Each patient consumed a normal diet (including gluten and casein) for 6 months and a GFCF diet for another 6 months. The order of the intervention (beginning with normal diet or with GFCF diet) was assigned randomly. Patients were evaluated at three time-points (at the beginning of the study, after normal diet and after GFCF diet). Questionnaires regarding behavior and autism and dietary adherence were completed and urinary beta-casomorphin concentrations were determined at each time-point. No significant behavioral changes and no association with urinary beta-casomorphin concentrations were found after GFCF diet. A 6-month GFCF diet do not induce significant changes in behavioral symptoms of autism and urinary beta-casomorphin concentrations. Further studies with a long follow-up period similar to ours and including placebo and blinding elements are needed to identify better those respondents to GFCF diets.

Keywords: Autism spectrum disorder; Beta-casomorphin; Casein; Diet; Gluten.

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References

    1. Nutr Diet Suppl. 2015;7:87-101 - PubMed

References

    1. Encephale. 2019 Sep;45(4):312-319 - PubMed

References

    1. J Ment Health Res Intellect Disabil. 2013 Oct;6(4):255-267 - PubMed

References

    1. Eur J Nutr. 2018 Mar;57(2):433-440 - PubMed

References

    1. Autism Res. 2018 Jan;11(1):185-193 - PubMed

References

    1. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD003498 - PubMed

References

    1. Psychopathology. 1999 Nov-Dec;32(6):292-300 - PubMed

References

    1. J Child Neurol. 2014 Dec;29(12):1718-27 - PubMed

References

    1. Ann Nutr Metab. 2007;51(3):228-31 - PubMed

References

    1. Microb Ecol Health Dis. 2012 Aug 24;23: - PubMed

References

    1. Pediatrics. 2017 Jun;139(6): - PubMed

References

    1. Cochrane Database Syst Rev. 2018 May 09;5:CD009260 - PubMed

References

    1. Pediatrics. 2012 Nov;130 Suppl 2:S77-82 - PubMed

References

    1. Nutrients. 2019 Aug 01;11(8): - PubMed

References

    1. J Prev Interv Community. 2006;32(1-2):25-39 - PubMed

References

    1. Nutr Neurosci. 2003 Feb;6(1):19-28 - PubMed

References

    1. Anal Bioanal Chem. 2007 Aug;388(8):1643-51 - PubMed

References

    1. Panminerva Med. 1995 Sep;37(3):137-41 - PubMed

References

    1. Biol Psychiatry. 2007 Feb 15;61(4):551-3 - PubMed

References

    1. J Autism Dev Disord. 1981 Dec;11(4):365-71 - PubMed

References

    1. Biomarkers. 2009 Dec;14(8):596-603 - PubMed

References

    1. Front Hum Neurosci. 2013 Jan 04;6:344 - PubMed

References

    1. Nutr Neurosci. 2012 Mar;15(2):85-91 - PubMed

References

    1. Nutr Neurosci. 2015 May;18(4):177-85 - PubMed

References

    1. Tunis Med. 2010 Sep;88(9):685-6 - PubMed

References

    1. J Autism Dev Disord. 2008 May;38(5):848-56 - PubMed

References

    1. J Autism Dev Disord. 1980 Mar;10(1):91-103 - PubMed

References

    1. J Autism Dev Disord. 1997 Apr;27(2):139-53 - PubMed

References

    1. Children (Basel). 2018 Feb 16;5(2): - PubMed

References

    1. J Autism Dev Disord. 2013 Jul;43(7):1623-9 - PubMed

References

    1. Peptides. 2014 Jun;56:68-71 - PubMed

References

    1. Dev Med Child Neurol. 2003 Feb;45(2):121-8 - PubMed

References

    1. Metab Brain Dis. 2017 Dec;32(6):1935-1941 - PubMed

References

    1. Res Autism Spectr Disord. 2015 Sep 1;17:40-51 - PubMed

References

    1. Nutrients. 2013 Sep 26;5(10):3839-53 - PubMed

References

    1. Nutrients. 2018 Mar 17;10(3): - PubMed

References

    1. Nutrients. 2019 Jan 04;11(1): - PubMed

References

    1. Pediatr Rev. 2013 Oct;34(10):e36-41 - PubMed

References

    1. Arch Dis Child. 2008 Sep;93(9):745-50 - PubMed

References

    1. Osteoporos Int. 2007 Dec;18(12):1601-7 - PubMed

References

    1. Peptides. 2015 Mar;65:6-11 - PubMed

References

    1. World J Pediatr. 2016 Nov;12(4):436-442 - PubMed

References

    1. J Am Acad Child Adolesc Psychiatry. 2014 Jun;53(6):658-66 - PubMed

References

    1. Nutr Neurosci. 2014 Sep;17(5):207-13 - PubMed

References

    1. Nutr Neurosci. 2002 Sep;5(4):251-61 - PubMed

References

    1. J Child Psychol Psychiatry. 2005 May;46(5):500-13 - PubMed

References

    1. J Hum Nutr Diet. 2002 Aug;15(4):261-9 - PubMed

References

    1. Autism Res. 2017 Mar;10(3):408-413 - PubMed

References

    1. Gut. 1979 Sep;20(9):743-9 - PubMed

References

    1. Cochrane Database Syst Rev. 2016 Jun 26;(6):CD009043 - PubMed

References

    1. Ann Paediatr. 1961;197:346-51 - PubMed

References

    1. Acta Paediatr. 2015 Nov;104(11):e500-5 - PubMed

References

    1. J Autism Dev Disord. 2006 Apr;36(3):413-20 - PubMed

References

    1. Curr Opin Clin Nutr Metab Care. 2015 Nov;18(6):572-5 - PubMed

References

    1. Nutr Neurosci. 2010 Apr;13(2):87-100 - PubMed

References

    1. J Autism Dev Disord. 2011 May;41(5):545-54 - PubMed

References

    1. J Am Acad Child Adolesc Psychiatry. 2012 Nov;51(11):1150-9 - PubMed

References

    1. Biol Psychiatry. 1986 Nov;21(13):1279-90 - PubMed

References

    1. J Autism Child Schizophr. 1971 Apr-Jun;1(2):119-45 - PubMed

References

    1. Microbiome. 2018 Aug 2;6(1):133 - PubMed

References

    1. Proc Nutr Soc. 2015 Aug;74(3):202-7 - PubMed

References

    1. J Autism Dev Disord. 2016 Jan;46(1):205-220 - PubMed

References

    1. J Altern Complement Med. 2010 May;16(5):555-60 - PubMed

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