Do Two Mitochondrial Wrongs Help Make Cells Right?

Ajit S Divakaruni; Anne N Murphy

doi:10.1016/j.molmed.2019.11.007

Do Two Mitochondrial Wrongs Help Make Cells Right?

Trends Mol Med. 2020 Jan;26(1):3-6. doi: 10.1016/j.molmed.2019.11.007. Epub 2019 Dec 5.

Authors

Ajit S Divakaruni¹, Anne N Murphy²

Affiliations

¹ Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA. Electronic address: adivakaruni@mednet.ucla.edu.
² Cytokinetics, South San Francisco, CA, USA. Electronic address: amurphy@cytokinetics.com.

PMID: 31813762
DOI: 10.1016/j.molmed.2019.11.007

Abstract

Using an unbiased genetic screen, To et al. map genes that enhance or suppress growth defects in response to different mitochondrial inhibitors to model mitochondrial disease. The findings have novel implications for the interconnectivity of bioenergetic pathways, and suggest a provocative strategy to treat primary mitochondrial disorders.

Keywords: CRISPR screen; GPX4; complex I; mitochondrial toxins.

Publication types

Comment

MeSH terms

Cell Line
Energy Metabolism
Humans
Mitochondria* / metabolism
Mitochondrial Diseases* / genetics
Mitochondrial Diseases* / metabolism
Mitochondrial Diseases* / therapy