Do Two Mitochondrial Wrongs Help Make Cells Right?

Trends Mol Med. 2020 Jan;26(1):3-6. doi: 10.1016/j.molmed.2019.11.007. Epub 2019 Dec 5.


Using an unbiased genetic screen, To et al. map genes that enhance or suppress growth defects in response to different mitochondrial inhibitors to model mitochondrial disease. The findings have novel implications for the interconnectivity of bioenergetic pathways, and suggest a provocative strategy to treat primary mitochondrial disorders.

Keywords: CRISPR screen; GPX4; complex I; mitochondrial toxins.

Publication types

  • Comment

MeSH terms

  • Cell Line
  • Energy Metabolism
  • Humans
  • Mitochondria* / metabolism
  • Mitochondrial Diseases* / genetics
  • Mitochondrial Diseases* / metabolism
  • Mitochondrial Diseases* / therapy