The Ventral Striatum is a Key Node for Functional Recovery of Finger Dexterity After Spinal Cord Injury in Monkeys

Cereb Cortex. 2020 May 14;30(5):3259-3270. doi: 10.1093/cercor/bhz307.

Abstract

In a recent study, we demonstrated that the ventral striatum (VSt) controls finger movements directly during the early recovery stage after spinal cord injury (SCI), implying that the VSt may be a part of neural substrates responsible for the recovery of dexterous finger movements. The VSt is accepted widely as a key node for motivation, but is not thought to be involved in the direct control of limb movements. Therefore, whether a causal relationship exists between the VSt and motor recovery after SCI is unknown, and the role of the VSt in the recovery of dexterous finger movements orfinger movements in general after SCI remains unclear. In the present study, functional brain imaging in a macaque model of SCI revealed a strengthened functional connectivity between motor-related areas and the VSt during the recovery process for precision grip, but not whole finger grip after SCI. Furthermore, permanent lesion of the VSt impeded the recoveryof precision grip, but not coarse grip. Thus, the VSt was needed specifically for functional recovery of dexterous finger movements. These results suggest that the VSt is the key node of the cortical reorganization required for functional recovery of finger dexterity.

Keywords: finger dexterity; functional recovery; nonhuman primate; plasticity; spinal cord injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fingers*
  • Functional Neuroimaging
  • GABA-A Receptor Agonists / pharmacology
  • Macaca
  • Motor Skills / drug effects
  • Motor Skills / physiology*
  • Muscimol / pharmacology
  • Positron-Emission Tomography
  • Recovery of Function / drug effects
  • Recovery of Function / physiology*
  • Spinal Cord Injuries / diagnostic imaging
  • Spinal Cord Injuries / physiopathology*
  • Ventral Striatum / diagnostic imaging
  • Ventral Striatum / drug effects
  • Ventral Striatum / physiology*

Substances

  • GABA-A Receptor Agonists
  • Muscimol