[Effect of a complex mixture of plasma proteins with heparin on the anticoagulation and fibrinolytic activity of the blood plasma in animals following intravenous administration of tissue thromboplastin]

Fiziol Zh SSSR Im I M Sechenova. 1988 Jun;74(6):814-9.
[Article in Russian]

Abstract

The i.v. administration of 1.5 ml of the heparin complexes with plasma proteins prior to the injection of tissue thromboplastin induced a stronger neutralization of formed thrombin in the blood and higher anticoagulating and fibrinolytic activities in albino rats as compared to the injection of tissue thromboplastin alone.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Blood Coagulation / drug effects*
  • Blood Proteins / pharmacology*
  • Drug Combinations
  • Fibrinogen / analysis
  • Fibrinolysis / drug effects*
  • Heparin / pharmacology*
  • Injections, Intravenous
  • Male
  • Rats
  • Thrombin / analysis
  • Thrombin Time
  • Thromboplastin / pharmacology*
  • Time Factors

Substances

  • Blood Proteins
  • Drug Combinations
  • Fibrinogen
  • Heparin
  • Thromboplastin
  • Thrombin