Primary central nervous system (CNS) lymphoma (PCNSL) is an uncommon extranodal non-Hodgkin lymphoma often presenting as a single brain lesion within the CNS. On histopathological evaluation of PCNSL a positive CD10, which is frequently observed in systemic diffuse large B-cell lymphoma, is present in approximately 10% of PCNSL. We describe a case of CD10-positive PCNSL presenting with multiple posterior fossa enhancing lesions in an immunocompetent older woman with a history of breast cancer successfully treated by the RTOG 0227 protocol consisting of pre-irradiation chemotherapy with high-dose methotrexate, rituximab, and temozolomide for 6 cycles, followed by low-dose whole-brain radiation and post-irradiation temozolomide.
Keywords: CD10; brain tumor; cerebellar tumor; lymphoma; primary CNS lymphoma.
Conflict of interest statement
High-dose Chemotherapy and Autologous Stem Cell Transplant Compared With Conventional Chemotherapy for Consolidation in Newly Diagnosed Primary CNS Lymphoma--A Randomized Phase III Trial (MATRix)E Schorb et al. BMC Cancer 16, 282. PMID 27098429. - Clinical TrialGerman clinical trials registry DRKS00005503 registered 22 April 2014 and ClinicalTrials.gov NCT02531841 registered 24 August 2015.
A Rare Case of Primary Central Nervous System Lymphoma in an Adolescent Female Treated With High-Dose Methotrexate and Rituximab-Based Chemoimmunotherapy and Consolidation Whole Brain RadiotherapyA Biswas et al. Pediatr Neurosurg 54 (1), 57-65. PMID 30669145. - Case ReportsPrimary central nervous system lymphoma (PCNSL) is a rare pediatric brain tumor. A 16-year-old female patient presented to the clinic with complaints of multiple episodes …
A Rare Case of Paediatric Primary Central Nervous System Lymphoma Treated With High-Dose Methotrexate and Rituximab-Based Chemoimmunotherapy and Whole Brain Radiotherapy Followed by Tumour Bed Boost With Three-Dimensional Conformal Radiation TechniqueN Adhikari et al. Childs Nerv Syst 34 (9), 1777-1783. PMID 29744624. - Case ReportsThis report highlights the fact that paediatric PCNSL may be effectively treated by a combination of HDMTX and rituximab-based chemoimmunotherapy followed by consolidatio …
Neuroinflammation Preceding and Accompanying Primary Central Nervous System Lymphoma: Case Study and Literature ReviewJQ Lu et al. World Neurosurg 88, 692.e1-692.e8. PMID 26724610. - ReviewPCNSL may be preceded and accompanied by an inflammatory process that is pathologically distinct from PCNSL. Our case study, in combination with a review of previously pu …
Case-based Review: Primary Central Nervous System LymphomaA Korfel et al. Neurooncol Pract 4 (1), 46-59. PMID 31386044. - ReviewPrimary CNS lymphoma (PCNSL) is a rare diffuse large B-cell lymphoma originating within the central nervous system. The overall incidence of PCNSL is rising, particularly …