Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a receptor for proteins targeted to mitochondria. TOMM20 was shown to be overexpressed in various cancers. However, the oncological function and therapeutic potential for TOMM20 in cancer remains largely unexplored. The purpose of this study was to elucidate the underlying molecular mechanism of TOMM20's contribution to tumorigenesis and to explore the possibility of its therapeutic potential using colorectal cancer as a model. The results show that TOMM20 overexpression resulted in an increase in cell proliferation, migration, and invasion of colorectal cancer (CRC) cells, while siRNA-mediated inhibition of TOMM20 resulted in significant decreases in cell proliferation, migration, and invasion. TOMM20 expression directly impacted the mitochondrial function including ATP production and maintenance of membrane potential, which contributed to tumorigenic cellular activities including regulation of S phase cell cycle and apoptosis. TOMM20 was overexpressed in CRC compared to the normal tissues and increased expression of TOMM20 to be associated with malignant characteristics including a higher number of lymph nodes and perineural invasion in CRC. Notably, knockdown of TOMM20 in the xenograft mouse model resulted in a significant reduction of tumor growth. This is the first report demonstrating a relationship between TOMM20 and tumorigenesis in colorectal cancer and providing promising evidence for the potential for TOMM20 to serve as a new therapeutic target of colorectal cancer. [BMB Reports 2019; 52(12): 712-717].
Conflict of interest statement
The authors have no conflicting interests.
Hodgkin Lymphoma: A Complex Metabolic Ecosystem With Glycolytic Reprogramming of the Tumor MicroenvironmentL Mikkilineni et al. Semin Oncol 44 (3), 218-225. PMID 29248133.Aggressive cHL exhibits features of metabolic heterogeneity with high mitochondrial metabolism in cancer cells and high glycolysis in TAMs, which is not seen in reactive …
Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid CancerJM Johnson et al. Semin Oncol 42 (6), 915-22. PMID 26615136.Anaplastic thyroid cancer (ATC) is one of the most aggressive human cancers. Key signal transduction pathways that regulate mitochondrial metabolism are frequently altere …
Overexpression of NELFCD Promotes Colorectal Cancer Cells Proliferation, Migration, and InvasionS Song et al. Onco Targets Ther 11, 8741-8750. PMID 30584332.NELFCD is overexpressed and plays an oncogenic role in CRC. Targeting NELFCD may provide a potential therapeutic option for NELFCD-amplified tumors.
Stromal-epithelial Metabolic Coupling in Gastric Cancer: Stromal MCT4 and Mitochondrial TOMM20 as Poor Prognostic FactorsZ Zhao et al. Eur J Surg Oncol 40 (10), 1361-8. PMID 24821064.Our findings directly support the existence of metabolic symbiosis in gastric cancer. Stromal MCT4 and mitochondrial TOMM20 could be promising biomarkers for predicting t …
Granulin Epithelin Precursor Promotes Colorectal Carcinogenesis by Activating MARK/ERK PathwayY Pan et al. J Transl Med 16 (1), 150. PMID 29866109.In summary, we compressively delineate the oncogenic role of GEP in colorectal tumorigenesis by activating MAPK/ERK signaling pathway. GEP might serve as a useful prognos …