Translocator protein (TSPO), also known as peripheral benzodiazepine receptor, is a transmembrane protein located on the outer mitochondria membrane (OMM) and mainly expressed in glial cells in the brain. Because of the close correlation of its expression level with neuropathology and therapeutic efficacies of several TSPO binding ligands under many neurological conditions, TSPO has been regarded as both biomarker and therapeutic target, and the biological functions of TSPO have been a major research focus. However, recent genetic studies with animal and cellular models revealed unexpected results contrary to the anticipated biological importance of TSPO and cast doubt on the action modes of the TSPO-binding drugs. In this review, we summarize recent controversial findings on the discrepancy between pharmacological and genetic studies of TSPO and suggest some future direction to understand this old and mysterious protein. [BMB Reports 2020; 53(1): 20-27].
Conflict of interest statement
The authors have no conflicting interests.
The 18-kDa Translocator Protein as a CNS Drug Target: Finding Our Way Through the Neuroinflammation FogMD Filiou et al. CNS Neurol Disord Drug Targets 16 (9), 990-999. PMID 28982340. - ReviewIn this review, we focus on psychiatric and neurodegenerative disorders, elaborate the role of TSPO and the effects of TSPO ligands on common disease phenotypes reviewing …
TSPO: An Evolutionarily Conserved Protein With Elusive FunctionsF Bonsack et al. Int J Mol Sci 19 (6). PMID 29875327. - ReviewTSPO (18 kDa translocator protein) was identified decades ago in a search for peripheral tissue binding sites for benzodiazepines, and was formerly called the peripheral …
The Translocator Protein (18kDa) and Its Role in Neuropsychiatric DisordersT Barichello et al. Neurosci Biobehav Rev 83, 183-199. PMID 29054730. - ReviewTranslocator protein (TSPO) is an 18kDa translocator membrane protein expressed in the outer mitochondrial membrane of steroid-synthesizing cells in the central and perip …
N-(6-[ 18 F]Fluoro-4-phenoxypyridin-3-yl)-N-(2-methoxybenzyl)acetamideA Chopra. PMID 23638491. - ReviewThe 18-kDa translocator protein (TSPO; also known as the peripheral benzodiazepine receptor (PBR)) is evolutionarily conserved and is found mainly in the outer membrane o …
Targeting and Insertion of the Cholesterol-Binding Translocator Protein Into the Outer Mitochondrial MembraneMB Rone et al. Biochemistry 48 (29), 6909-20. PMID 19552401.Translocator protein (18 kDa, TSPO), previously known as the peripheral-type benzodiazepine receptor, is an outer mitochondrial membrane (OMM) protein necessary for chole …