Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 15, 1343-1350
eCollection

Incidence Of Clostridium difficile Infection And Associated Risk Factors Among Hospitalized Children In Qatar

Affiliations

Incidence Of Clostridium difficile Infection And Associated Risk Factors Among Hospitalized Children In Qatar

Ahmed Khalil et al. Ther Clin Risk Manag.

Abstract

Background: Clostridium difficile infection (CDI) is the single most common cause of nosocomial diarrhea in both adults and children. There is a deficiency in the literature regarding the incidence and associated risk factors in hospitalized children. This study aimed to determine the incidence of CDI and its associated risk factors.

Methods: A retrospective study was conducted among 200 pediatric patients admitted to the pediatric ward at Hamad General Hospital (HGH) in Qatar. The study collected data from January 1, 2015 till December 2015. Univariate and multivariate logistic regression methods were used to assess each risk factor of CDI.

Results: Among the 200 patients, 23 were diagnosed with CDI (incidence: 5.9 per 1000 inpatient admission cases). The mean patient age (±SD) was 6.4 ± 3.4 years. The incidence of antibiotic exposure (22.5; 95% CI: 15.0-38.7; P <0.001), prolonged hospitalization (28.9; 95% CI: 17.1-43.3; P <0.001), and enteral feeding (33.3; 95% CI: 15.9-55.1; P <0.001) were significant risk factors for CDI.

Conclusion: Antibiotics exposure, prolonged hospitalization, and enteral feeding were significant risk factors of CDI in hospitalized children; thus, emphasizing the importance of antimicrobial stewardship programs in the prevention of hospital-associated infection. Further prospective studies are needed to assess the trend in incidence and to identify other risk factors of CDI.

Keywords: Clostridium difficile infection (CDI); antimicrobial stewardship; hospital acquired; hospitalized pediatric patients; risk factors.

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Common antibiotics used prior to C. difficile infection.

Similar articles

See all similar articles

References

    1. Hall IC, O’Toole EL. Intestinal flora in new-born infants: with a description of a new pathogenic anaerobe, Bacillus difficilis. Am J Dis Child. 1935;49:390–402. doi:10.1001/archpedi.1935.01970020105010 - DOI
    1. George RH, Symonds JM, Dimock F, et al. Identification of Clostridium difficile as a cause of pseudomembranous colitis. BMJ. 1978;1:695. doi:10.1136/bmj.1.6114.695 - DOI - PMC - PubMed
    1. Larson HE, Price AB, Honour P, et al. Clostridium difficile and the etiology of pseudomembranous colitis. The Lancet. 1978;311:1063–1066. doi:10.1016/S0140-6736(78)90912-1 - DOI - PubMed
    1. Dubberke ER, Gerding DN, Classen D, et al. Strategies to prevent Clostridium difficile infections in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29Suppl 1:S81–92. - PubMed
    1. Langley JM, LeBlanc JC, Hanakowski M, et al. The role of Clostridium difficile and viruses as causes of nosocomial diarrhea in children. Infect Control Hosp Epidemiol. 2002;23:660–664. - PubMed

LinkOut - more resources

Feedback