Field cancerization treatment using topical photodynamic therapy: A comparison between two aminolevulinate derivatives

Elisangela Ramos de Oliveira; Natalia M Inada; Kate Cristina Blanco; Vanderlei S Bagnato; Ana Gabriela Salvio

doi:10.1016/j.pdpdt.2019.101603

Field cancerization treatment using topical photodynamic therapy: A comparison between two aminolevulinate derivatives

Photodiagnosis Photodyn Ther. 2020 Jun:30:101603. doi: 10.1016/j.pdpdt.2019.101603. Epub 2019 Dec 9.

Authors

Elisangela Ramos de Oliveira¹, Natalia M Inada², Kate Cristina Blanco³, Vanderlei S Bagnato², Ana Gabriela Salvio¹

Affiliations

¹ Hospital Amaral Carvalho, Jaú, SP, Brazil.
² São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil.
³ São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, Brazil. Electronic address: blancokate@gmail.com.

PMID: 31821900
DOI: 10.1016/j.pdpdt.2019.101603

Abstract

The objective of this study was to evaluate and compare the clinical response to PDT (Photodynamic Therapy) in field cancerization using two aminolevulinate derivatives. Forty patients with multiple actinic keratosis (AK) on forearms and hands scattered received two sessions of ALA and MAL-PDT at 630 nm (36 J/cm²). The AK clearance rate was 72 % for both drugs with a significant decrease in AK observed clinically (p < 00,001). Clinical improvement in field cancerization using two aminolevulinate derivatives in PDT is proven with no significant difference in the efficacy of drugs.

Keywords: 5 - aminolevulinic acid; Actinic keratosis; Methyl aminolevulinate acid; Nonmelanoma cancer; Photodynamic Thrapy.

MeSH terms

Aminolevulinic Acid / therapeutic use
Humans
Keratosis, Actinic* / drug therapy
Photochemotherapy* / methods
Photosensitizing Agents / therapeutic use
Treatment Outcome

Substances

Photosensitizing Agents
Aminolevulinic Acid