Nephroprotective effect of N-acetylglucosamine in rats with acute kidney injury

Ceska Slov Farm. Summer 2019;68(4):173-179.

Abstract

The article presents the results of the study of the nephroprotective effect of N-acetylglucosamine (NAG) under the development of experimental acute kidney injury (AKI). The study was conducted on a model of acute glycerol nephrosis in rats. NAG was studied at a dose of 50 mg/kg at daily parenteral administration during 1 week compared to quercetin, which was administered intraperitoneally at a dose of 34 mg/kg. The efficiency of the drugs was assessed by the functional state of animals, the renal excretory function and the nitrogen metabolism indices. The NAG effect on rats with AKI caused a reduction of the mortality rate, an increase in diuresis, a reduction of proteinuria, an increase in creatinine and urea excretion, which indicates the normalization of the renal excretory function and nitrogen metabolism. At the same time, NAG has statistically significantly exceeded the effect of quercetin in the majority of indices and, therefore, the level of efficiency. Thus, NAG is an efficient agent for AKI treatment, which can be used at parenteral route of administration.

Keywords: N-acetylglucosamine; experimental acute kidney injury; nephroprotective effect.

MeSH terms

  • Acetylglucosamine / pharmacology*
  • Acute Kidney Injury / drug therapy*
  • Animals
  • Creatinine / urine
  • Diuresis
  • Proteinuria
  • Quercetin / pharmacology
  • Rats
  • Urea / urine

Substances

  • Urea
  • Quercetin
  • Creatinine
  • Acetylglucosamine