Sex Differences in Cognitive Changes in De Novo Parkinson's Disease

J Int Neuropsychol Soc. 2020 Feb;26(2):241-249. doi: 10.1017/S1355617719001085. Epub 2019 Dec 11.


Objective: To evaluate the sex differences in cognitive course over 4 years in Parkinson's disease (PD) patients with and without mild cognitive impairment (MCI) compared to controls.

Methods: Four-year longitudinal cognitive scores of 257 cognitively intact PD, 167 PD-MCI, and 140 controls from the Parkinson's Progression Markers Initiative were included. Longitudinal scores of men and women, and PD with and without MCI were compared.

Results: Women had better verbal memory, men had better visuospatial function. There was no interaction between sex, diagnostic group, and/or time (4-year follow-up period).

Conclusions: Sex differences in cognitive course in de novo PD are similar to healthy aging. Cognitive decline rates in PD with and without MCI are similar for the first 4 years of PD.

Keywords: Cognition; Decline; Longitudinal studies; Memory; Parkinson’s disease; Sex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cognitive Aging / physiology*
  • Cognitive Dysfunction / etiology
  • Cognitive Dysfunction / physiopathology*
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Parkinson Disease / complications
  • Parkinson Disease / physiopathology*
  • Sex Characteristics*