The role of enhancer RNAs in epigenetic regulation of gene expression

Transcription. 2020 Feb;11(1):19-25. doi: 10.1080/21541264.2019.1698934. Epub 2019 Dec 11.


Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.

Keywords: BRD4; Enhancer; bromodomain; chromatin; eRNA; gene regulation; histone modification; transcription.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Enhancer Elements, Genetic / genetics*
  • Epigenesis, Genetic / genetics*
  • Gene Expression Regulation / genetics
  • Humans
  • RNA / genetics*


  • RNA