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Understanding Diverse TRPV1 Signaling - An Update

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Understanding Diverse TRPV1 Signaling - An Update

Michael Andresen. F1000Res.

Abstract

The transient receptor potential vanilloid 1 (TRPV1) is densely expressed in spinal sensory neurons as well as in cranial sensory neurons, including their central terminal endings. Recent work in the less familiar cranial sensory neurons, despite their many similarities with spinal sensory neurons, suggest that TRPV1 acts as a calcium channel to release a discrete population of synaptic vesicles. The modular and independent regulation of release offers new questions about nanodomain organization of release and selective actions of G protein-coupled receptors.

Keywords: NTS; TRPV1; cranial nerve; solitary tract nucleus; synaptic transmission; vagus; visceral afferent.

Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

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This work was supported by grants from the National Institutes of Health, HL-133505 (MCA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung and Blood Institute or the NIH.

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