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Understanding Diverse TRPV1 Signaling - An Update


Understanding Diverse TRPV1 Signaling - An Update

Michael Andresen. F1000Res.


The transient receptor potential vanilloid 1 (TRPV1) is densely expressed in spinal sensory neurons as well as in cranial sensory neurons, including their central terminal endings. Recent work in the less familiar cranial sensory neurons, despite their many similarities with spinal sensory neurons, suggest that TRPV1 acts as a calcium channel to release a discrete population of synaptic vesicles. The modular and independent regulation of release offers new questions about nanodomain organization of release and selective actions of G protein-coupled receptors.

Keywords: NTS; TRPV1; cranial nerve; solitary tract nucleus; synaptic transmission; vagus; visceral afferent.

Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

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    1. Caterina MJ, Schumacher MA, Tominaga M, et al. : The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997;389(6653):816–24. 10.1038/39807 - DOI - PubMed
    1. Julius D: TRP channels and pain. Annu Rev Cell Dev Biol. 2013;29:355–84. 10.1146/annurev-cellbio-101011-155833 - DOI - PubMed
    1. Fitzgerald M: Capsaicin and sensory neurones--a review. Pain. 1983;15(2):109–30. 10.1016/0304-3959(83)90012-x - DOI - PubMed
    1. Buck SH, Burks TF: The neuropharmacology of capsaicin: review of some recent observations. Pharmacol Rev. 1986;38(3):179–226. - PubMed
    1. Chiou KL, Hastorf CA, Bonavia D, et al. : Documenting Cultural Selection Pressure Changes on Chile Pepper ( Capsicum baccatum L.) Seed Size Through Time in Coastal Peru (7,600 B.P.–Present). Econ Bot. 2014;68:190–202. 10.1007/s12231-014-9270-y - DOI

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This work was supported by grants from the National Institutes of Health, HL-133505 (MCA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung and Blood Institute or the NIH.

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