Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 263 (33), 17217-20

The Structural Genes for Alpha 1 and Alpha 2 Chains of Human Type IV Collagen Are Divergently Encoded on Opposite DNA Strands and Have an Overlapping Promoter Region

Affiliations
  • PMID: 3182844

The Structural Genes for Alpha 1 and Alpha 2 Chains of Human Type IV Collagen Are Divergently Encoded on Opposite DNA Strands and Have an Overlapping Promoter Region

R Soininen et al. J Biol Chem.

Abstract

Many of the genes of simple organisms with small genomes are encoded on opposite DNA strands so that the genes either overlap or one gene is nested within another gene (Normark, S., Bergström, S., Edlund, T., Grundström, T., Jaurin, B., Lindberg, F.P., and Olsson, D. (1983) Annu. Rev. Genet. 17, 499-525; Chen, C., Malone, T., Beckendorf, S.K., and Davis, R.L. Nature (1987) 329, 721-724). In contrast, most of the genes of complex organisms are dispersed in the genome in widely separated locations. Here, we report that the genes for the alpha 1 and alpha 2 chains of human type IV collagen are encoded on opposite DNA strands from loci that are so closely located that they may be separated by as little as 42 base pairs. The results provide the first description of two structural genes from a complex organism that code for two polypeptide chains of the same protein molecule but have overlapping 5'-flanking regions.

Similar articles

See all similar articles

Cited by 28 articles

See all "Cited by" articles

Publication types

Associated data

LinkOut - more resources

Feedback