Comparison of parathyroid hormone kinetics in endoscopic thyroidectomy via bilateral areola with open thyroidectomy

BMC Surg. 2019 Dec 11;19(1):190. doi: 10.1186/s12893-019-0656-8.


Background: In this study, we aimed to compare the kinetics of intact parathyroid hormone (iPTH) during the perioperative period of endoscopic thyroidectomy via bilateral areola approach (ETBAA) in the same period, following a traditional open thyroidectomy approach (OTA).

Methods: We conducted a prospective observational study of patients who were undergoing thyroidectomy and level VI clearance. Patients who had been affected by papillary thyroid cancer (PTC) were stratified into three groups: those eligible for endoscopic treatment (ETBAA); patients who were eligible for ETBAA but had opted for OTA (OTA-L); and patients who were not suitable for endoscopic intervention (OTA-H). A process for locating parathyroid glands was utilized to stratify gland dissection laboriousness. In Type A, the gland is firmly fixed to thyroid gland. This type can be sub-classified into three subtypes. A1: the parathyroid gland is attached to the inherent thyroid capsule. A2: the gland is partially embedded in the thyroid gland. A3: the gland is located in the thyroid tissue. Type B is defined as a gland which is separated from the thyroid gland. The iPTH was sampled at wound closure.

Results: There were 100 patients in each group. We found a significant difference between the ETBAA and OTA-H groups for type A2, as well as a loss of parathyroid glands and a number of parathyroid transplantation procedures. The endoscopic group was treated during an earlier stage of thyroid cancer. The iPTH profile of each group decreased, although this was the most consistent in the OTA-H group. A comparison of ETBAA with OTA-L demonstrates that the iPTH level change is similar.

Conclusion: There is no advantage of endoscopic treatment for preserving parathyroid function.

Keywords: Central compartment lymph node dissection; Hypocalcemia; Intact PTH (iPTH); Morbidity; Thyroid surgery.

Publication types

  • Comparative Study
  • Observational Study

MeSH terms

  • Adult
  • Endoscopy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neck Dissection
  • Nipples
  • Parathyroid Glands / surgery
  • Parathyroid Hormone / metabolism*
  • Prospective Studies
  • Thyroid Cancer, Papillary / surgery*
  • Thyroid Neoplasms / surgery*
  • Thyroidectomy / adverse effects
  • Thyroidectomy / methods*
  • Young Adult


  • Parathyroid Hormone