Generation of ECG signals from a reaction-diffusion model spatially discretized

Sci Rep. 2019 Dec 12;9(1):19000. doi: 10.1038/s41598-019-55448-5.


We propose a model to generate electrocardiogram signals based on a discretized reaction-diffusion system to produce a set of three nonlinear oscillators that simulate the main pacemakers in the heart. The model reproduces electrocardiograms from healthy hearts and from patients suffering various well-known rhythm disorders. In particular, it is shown that under ventricular fibrillation, the electrocardiogram signal is chaotic and the transition from sinus rhythm to chaos is consistent with the Ruelle-Takens-Newhouse route to chaos, as experimental studies indicate. The proposed model constitutes a useful tool for research, medical education, and clinical testing purposes. An electronic device based on the model was built for these purposes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arrhythmias, Cardiac / diagnostic imaging
  • Computer Simulation
  • Diffusion
  • Electrocardiography*
  • Models, Cardiovascular*
  • Nonlinear Dynamics
  • Numerical Analysis, Computer-Assisted
  • Signal Processing, Computer-Assisted*
  • Time Factors
  • Ventricular Fibrillation / diagnostic imaging