Background: The management of chronic degenerative joint disorders such as osteoarthritis (OA) with ayurvedic medicines provides a safe and effective alternative. Ayurvedic medicines possess analgesic, anti-inflammatory, anti-oxidant and immunomodulator activities.
Aims: The main aim of the study was to assess the efficacy of Ayuartis capsule in patients suffering from OA of the knee(s).
Materials and methods: Thirty-one patients suffering from OA knee(s) were recruited after evaluating them as per inclusion/exclusion criteria. Patients were advised to take two Ayuartis capsules twice daily orally for 90 days. Knee joint(s) pain was assessed on the Visual Analog Scale. Patients' joint pain, stiffness, and physical functions were assessed on the Western Ontario McMaster University Osteoarthritis (WOMAC) index. Quality of life (QOL) and the time required to walk 50 feet was evaluated. Patients were called for follow-up visits on every 15th day till 90 days. Adverse events and vitals were recorded at every visit. Safety laboratory investigations were done before and after the completion of trial.
Statistical analysis: Data describing quantitative measures are expressed as mean ± standard deviation. The comparison of variables representing categorical data was performed using pair t-test.
Results: The mean joint pain reduced significantly by 53.82% on day 90. The mean WOMAC combined score, pain score, stiffness score and difficulty score reduced significantly by 50.88%, 54.96%, 58.76% and 49.02%, respectively on day 90. A significant improvement was observed in mean QOL of patients. A significant reduction in mean time required to walk 50 feet was observed. Majority of the patients had shown good overall improvement and excellent tolerability to the trial drug.
Conclusion: Ayuartis capsule is a safe and effective medicine for the treatment of OA of the knee(s).
Keywords: Ayuartis capsules; Visual Analog Scale; Western Ontario McMaster University Osteoarthritis; osteoarthritis; quality of life.
Copyright: © 2019 AYU (An International Quarterly Journal of Research in Ayurveda).
Conflict of interest statement
There are no conflicts of interest.
An open label, prospective, clinical study on a polyherbal formulation in osteoarthritis of knee.J Ayurveda Integr Med. 2013 Jan;4(1):33-9. doi: 10.4103/0975-9476.109549. J Ayurveda Integr Med. 2013. PMID: 23741160 Free PMC article.
A clinical study to evaluate efficacy and safety of AHPL/AYTAB/0313 tablet in subjects suffering from osteoarthritis of knee(s).J Family Med Prim Care. 2020 Jan 28;9(1):61-68. doi: 10.4103/jfmpc.jfmpc_321_18. eCollection 2020 Jan. J Family Med Prim Care. 2020. PMID: 32110566 Free PMC article.
Efficacy and tolerability of once-daily OROS hydromorphone and twice-daily extended-release oxycodone in patients with chronic, moderate to severe osteoarthritis pain: results of a 6-week, randomized, open-label, noninferiority analysis.Clin Ther. 2007 May;29(5):874-888. doi: 10.1016/j.clinthera.2007.05.016. Clin Ther. 2007. PMID: 17697906 Clinical Trial.
Braces and orthoses for treating osteoarthritis of the knee.Cochrane Database Syst Rev. 2015 Mar 16;(3):CD004020. doi: 10.1002/14651858.CD004020.pub3. Cochrane Database Syst Rev. 2015. PMID: 25773267 Review.
Celecoxib for osteoarthritis.Cochrane Database Syst Rev. 2017 May 22;5(5):CD009865. doi: 10.1002/14651858.CD009865.pub2. Cochrane Database Syst Rev. 2017. PMID: 28530031 Free PMC article. Review.
- Mahajan A, Verma S, Tandon V. Osteoarthritis. J Assoc Physicians India. 2005;53:634–41. - PubMed
- Hochberg MC, Altman RD, Brandt KD, Clark BM, Dieppe PA, Griffin MR, et al. Guidelines for the medical management of osteoarthritis. Arthritis Rheum. 1995;38:1535–40. - PubMed
- Alcaraz MJ, Megías J, García-Arnandis I, Clérigues V, Guillén MI. New molecular targets for the treatment of osteoarthritis. Biochem Pharmacol. 2010;80:13–21. - PubMed
- Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, et al. Osteoarthritis: New insights. Part 1: The disease and its risk factors. Ann Intern Med. 2000;133:635–46. - PubMed