Position Statement on the Use of Bone Turnover Markers for Osteoporosis Treatment

So Young Park; Seong Hee Ahn; Jun-Il Yoo; Youn-Jee Chung; Yun Kyung Jeon; Byung-Ho Yoon; Ha Young Kim; Seung Hun Lee; Jehoon Lee; Seongbin Hong

doi:10.11005/jbm.2019.26.4.213

Position Statement on the Use of Bone Turnover Markers for Osteoporosis Treatment

J Bone Metab. 2019 Nov;26(4):213-224. doi: 10.11005/jbm.2019.26.4.213. Epub 2019 Nov 30.

Authors

So Young Park¹, Seong Hee Ahn², Jun-Il Yoo³, Youn-Jee Chung⁴, Yun Kyung Jeon⁵, Byung-Ho Yoon⁶, Ha Young Kim⁷, Seung Hun Lee⁸, Jehoon Lee⁹, Seongbin Hong²

Affiliations

¹ Division of Endocrinology and Metabolism, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.
² Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
³ Department of Orthopaedic Surgery, Gyeongsang National University Hospital, Jinju, Korea.
⁴ Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
⁵ Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
⁶ Department of Orthopaedic Surgery, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
⁷ Division of Endocrinology, Department of Internal Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Korea.
⁸ Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
⁹ Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

Current evidences continue to support the clinical application of bone turnover markers (BTMs) in the management of postmenopausal osteoporosis. The limitations of bone mineral density measured by dual energy X-ray absorptiomet especially emphasize the beneficial roles of BTMs, such as serum C-terminal telopeptide of type I collagen and serum procollagen type I N-propeptide, as monitoring tools to assess the responses to treatment. Therefore, the proper application and assessment of BTM in clinical practice is very important. However, their use in Korea is still insufficient. Therefore, the BTM committee has set up by the Korean Society for Bone and Mineral Research have been constituted and provided a position statement which will suggest on the clinical application of BTM for the management of postmenopausal osteoporosis in Korea.

Keywords: Bone remodeling; Osteoporosis; Republic of Korea.

Publication types

Review