Monocyte Subsets Are Differently Associated with Infarct Size, Left Ventricular Function, and the Formation of a Potentially Arrhythmogenic Scar in Patients with Acute Myocardial Infarction

J Cardiovasc Transl Res. 2020 Oct;13(5):722-730. doi: 10.1007/s12265-019-09944-8. Epub 2019 Dec 12.


To investigate the role of classical (CLM, CD14++CD16-), intermediate (INTM, CD14++CD16+), and non-classical (Non-CLM, CD14+CD16++) monocytes in scar formation after ST-elevation myocardial infarction (STEMI), evaluated with cardiac magnetic resonance (CMR). One hundred two patients with a first STEMI had serial blood analyses after 1, 3, and 7 days. A CMR was performed at 7 days and 6 months, depicting scar core (CO), border zone (BZ), and the presence of BZ channels. CLM and INTM levels progressively decreased, correlated with the scar mass, CO, and BZ at 7 days and 6 months (p < 0.05), and inversely with left ventricular ejection fraction (LVEF, p < 0.01). Non-CLM levels gradually increased, correlated with BZ mass and the presence of BZ channels at 7 days and 6 months (p < 0.001).CLM and INTM are associated with infarct size and inversely with LVEF, whereas Non-CLM are associated with BZ mass and the presence of potentially arrhythmogenic substrate.

Keywords: Arrhythmogenic substrate; Left ventricular function; Monocytes; Myocardial infarction.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Arrhythmias, Cardiac / etiology*
  • Arrhythmias, Cardiac / immunology
  • Arrhythmias, Cardiac / physiopathology
  • Biomarkers / blood
  • Female
  • GPI-Linked Proteins / blood
  • Humans
  • Lipopolysaccharide Receptors / blood
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Monocytes / classification
  • Monocytes / immunology*
  • Myocardium / pathology*
  • Percutaneous Coronary Intervention
  • Prospective Studies
  • Receptors, IgG / blood
  • Risk Factors
  • ST Elevation Myocardial Infarction / complications*
  • ST Elevation Myocardial Infarction / immunology
  • ST Elevation Myocardial Infarction / physiopathology
  • ST Elevation Myocardial Infarction / therapy
  • Stroke Volume*
  • Time Factors
  • Treatment Outcome
  • Ventricular Function, Left*
  • Ventricular Remodeling*


  • Biomarkers
  • CD14 protein, human
  • FCGR3B protein, human
  • GPI-Linked Proteins
  • Lipopolysaccharide Receptors
  • Receptors, IgG