FG-nucleoporins caught in the act of liquid-liquid phase separation

J Cell Biol. 2020 Jan 6;219(1):e201910211. doi: 10.1083/jcb.201910211.

Abstract

The interior of nuclear pore complexes (NPCs) is densely filled with FG-nucleoporins that form a permeability barrier of a still-obscure nature. Celetti et al. (2019. J. Cell Biol.https://doi.org/10.1083/jcb.201907157) now reveal that FG-nucleoporins can undergo liquid-liquid phase separation and form liquid droplets that mimic permeability barrier properties of intact NPCs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Active Transport, Cell Nucleus
  • Nuclear Pore Complex Proteins*
  • Nuclear Pore*
  • Permeability

Substances

  • Nuclear Pore Complex Proteins