Neuroprotective effects of Bacopa monnieri in Parkinson's disease model

Metab Brain Dis. 2020 Mar;35(3):517-525. doi: 10.1007/s11011-019-00526-w. Epub 2019 Dec 13.


Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of dopaminergic neurons in substantia nigra region and the presence of α-synuclein aggregates in the striatum and surrounding areas of brain. Evidences suggest that neuroinflammation plays a role in the progression of PD. We examined the neuro-protective effects of Bacopa monnieri (BM) in regulating neuroinflammation. Administration of BM suppressed the level of pro-inflammatory cytokines, decreased the levels of α-synuclein, and reduced reactive oxygen species (ROS) generation in PD animal model. Pre-treatment of BM showed more prominent results as compare to co- and post-treatment. Results suggest that Bacopa can limit inflammation in the different areas of brain, thus, offers a promising source of novel therapeutics for the treatment of many CNS disorders.

Keywords: Bacopa monnieri; Cytokines; Neurodegeneration; Parkinson’s disease; ROS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacopa*
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism
  • Chemokine CCL4 / metabolism
  • Disease Models, Animal
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Interleukin-1beta / metabolism
  • Interleukin-6 / metabolism
  • Male
  • Neuroprotective Agents / pharmacology
  • Neuroprotective Agents / therapeutic use*
  • Oxidative Stress / drug effects*
  • Parkinson Disease, Secondary / chemically induced
  • Parkinson Disease, Secondary / drug therapy*
  • Parkinson Disease, Secondary / metabolism
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Rats
  • Rats, Wistar
  • Reactive Oxygen Species / metabolism
  • Rotenone
  • Substantia Nigra / drug effects
  • Substantia Nigra / metabolism
  • Tumor Necrosis Factor-alpha / metabolism
  • alpha-Synuclein / metabolism


  • Chemokine CCL4
  • Interleukin-1beta
  • Interleukin-6
  • Neuroprotective Agents
  • Plant Extracts
  • Reactive Oxygen Species
  • Tumor Necrosis Factor-alpha
  • alpha-Synuclein
  • Rotenone