Review of Ginseng Anti-Diabetic Studies

Molecules. 2019 Dec 9;24(24):4501. doi: 10.3390/molecules24244501.


Ginseng is one of the most valuable and commonly used Chinese medicines not only in ancient China but also worldwide. Ginsenosides, also known as saponins or triterpenoids, are thought to be responsible for the beneficial effects of ginseng. In this review, we summarize recent publications on anti-diabetic studies of ginseng extracts and ginsenosides in cells, animals, and humans. It seems that the anti-diabetic effect of ginseng is positive for type 2 diabetic patients but has no significant impact on prediabetes or healthy adults. Regulation of insulin secretion, glucose uptake, anti-oxidative stress, and anti-inflammatory pathways may be the mechanisms involved with ginseng's anti-diabetic effects. Taken together, this summary provides evidence for the anti-diabetes effects of ginseng extracts and ginsenosides as well as the underlying mechanisms of their impact on diabetes.

Keywords: anti-diabetes; blood glucose; ginseng; ginsenosides; insulin.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Glucose / drug effects
  • Clinical Trials as Topic
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / etiology
  • Diabetes Mellitus / metabolism
  • Drug Evaluation, Preclinical
  • Ginsenosides / chemistry
  • Ginsenosides / pharmacology*
  • Ginsenosides / therapeutic use*
  • Humans
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology*
  • Hypoglycemic Agents / therapeutic use*
  • Molecular Structure
  • Panax / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use*
  • Treatment Outcome


  • Blood Glucose
  • Ginsenosides
  • Hypoglycemic Agents
  • Plant Extracts