The Tumor Vessel Targeting Strategy: A Double-Edged Sword in Tumor Metastasis

Xiaobo Li; Yong Li; Weijin Lu; Minfeng Chen; Wencai Ye; Dongmei Zhang

doi:10.3390/cells8121602

The Tumor Vessel Targeting Strategy: A Double-Edged Sword in Tumor Metastasis

Cells. 2019 Dec 10;8(12):1602. doi: 10.3390/cells8121602.

Authors

Xiaobo Li^{1

2}, Yong Li^{1

2}, Weijin Lu^{1

2}, Minfeng Chen^{1

2}, Wencai Ye^{1

2}, Dongmei Zhang^{1

2}

Affiliations

¹ College of Pharmacy, Jinan University, No. 601, Huangpu Road West, Guangzhou 510632, China.
² Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.

Abstract

Tumor vessels provide essential paths for tumor cells to escape from the primary tumor and form metastatic foci in distant organs. The vessel targeting strategy has been widely used as an important clinical cancer chemotherapeutic strategy for patients with metastatic tumors. Our review introduces the contribution of angiogenesis to tumor metastasis and summarizes the application of Food and Drug Administration (FDA)-approved vessel targeting drugs for metastatic tumors. We recommend the application and mechanisms of vascular targeting drugs for inhibiting tumor metastasis and discuss the risk and corresponding countermeasures after vessel targeting treatment.

Keywords: angiogenesis; pro-metastasis risk; tumor metastasis; vessel targeting drugs.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antineoplastic Agents / therapeutic use*
Humans
Neoplasm Metastasis / drug therapy
Neoplasms / drug therapy*
Neovascularization, Pathologic / drug therapy*

Substances

Antineoplastic Agents