Treatment with brentuximab vedotin plus bendamustine in unselected patients with CD30-positive aggressive lymphomas

Eur J Haematol. 2020 Mar;104(3):251-258. doi: 10.1111/ejh.13368. Epub 2020 Jan 10.


Objectives: A treatment regimen consisting of bendamustine and brentuximab vedotin (BV) has been described as a highly potent salvage therapy and as an effective induction therapy leading to high response rates before autologous stem cell transplantation (ASCT) in patients with classical Hodgkin lymphoma (cHL). In this retrospective analysis, we aimed to assess this therapy's efficacy in unselected patients with cHL and CD30+ peripheral T-cell lymphoma (PTCL).

Patients and methods: Data of 28 patients with cHL and five patients with PTCL treated with a combination of bendamustine and BV at three Austrian tertiary cancer centers were analyzed.

Results: In patients with cHL, the ORR was 100% (78.6% CR, 21.4% PR). After 17 months median follow-up, median survival times were not reached; 1-year PFS was 81.9%, and 1-year OS was 95.7%. Thirteen eligible patients (46.4%) successfully underwent planned ASCT after salvage therapy with bendamustine and BV and subsequent high-dose chemotherapy. Three of the five PTCL patients achieved CR, while two did not respond and died during or shortly after therapy.

Conclusion: A combination of bendamustine and BV is an effective salvage and induction therapy before ASCT in patients with relapsed/refractory cHL. Further research is warranted to evaluate the use in patients with PTCL.

Keywords: Hodgkin lymphoma; PTCL; bendamustine; brentuximab vedotin; induction therapy; peripheral T-cell lymphoma; salvage therapy.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bendamustine Hydrochloride / administration & dosage
  • Brentuximab Vedotin / administration & dosage
  • Child
  • Combined Modality Therapy
  • Female
  • Hodgkin Disease / diagnosis
  • Hodgkin Disease / drug therapy*
  • Hodgkin Disease / etiology
  • Humans
  • Induction Chemotherapy
  • Ki-1 Antigen / metabolism
  • Lymphoma, T-Cell, Peripheral / diagnosis
  • Lymphoma, T-Cell, Peripheral / drug therapy*
  • Lymphoma, T-Cell, Peripheral / etiology
  • Lymphoma, T-Cell, Peripheral / metabolism
  • Male
  • Middle Aged
  • Prognosis
  • Treatment Outcome
  • Young Adult


  • Ki-1 Antigen
  • Brentuximab Vedotin
  • Bendamustine Hydrochloride