Objective: To investigate the expression level of T lymphocyte subsets in elderly patients with newly diagnosed multiple myeloma (NDMM), and to evaluated the prognostic value of T lymphocytic abnormalities in elderly NDMM patients.
Methods: Pretreated peripheral blood of 39 newly diagnosed elder patients with MM was tested by multi-parameter flow cytometry (MFC) to quantitatively detect T lymphocyte subsets, including CD4+T cell, CD8+T cell, and CD4/CD8 ratio. The prognostic values T-lymphocyte subset were evaluated in newly diagnosed elderly patients with MM.
Results: The median follow-up time was 21.5 (range, 3.0-66.0) months. Absolute counts of CD4+T cell and CD4/CD8 ratio positively correlated with prognosis. In the multivariate COX analysis, lower CD4/CD8 ratio and CD4+T cell counts were identified to be independent adverse prognostic factors for OS.
Conclusion: Lower CD4/CD8 ratio and CD4+T cell counts at initial diagnosis are independent unfavorable prognostic factors for elderly patients with MM, and T lymphocyte subsets are crucial indicators for MM patients' prognosis.
题目: 外周血T淋巴细胞亚群与初诊老年多发性骨髓瘤患者预后的相关性.
目的: 检测初诊老年多发性骨髓瘤（MM）患者外周血中T淋巴细胞亚群的表达水平，以评估T淋巴细胞亚群在初诊老年MM患者中的预后价值.
方法: 通过多参数流式细胞术（MFC）定量检测39例初诊老年MM患者外周血中的T淋巴细胞亚群，包括CD4+T细胞和CD8+T细胞的比例和绝对计数，以及CD4/CD8比值，评估T细胞亚群表达水平在初诊老年MM患者中的预后价值.
结果: 中位随访时间为21.5（3.0-66.0）个月。生存分析结果显示，CD4+T细胞绝对值、CD4/CD8比值与预后正相关。多因素COX分析提示，低CD4+T细胞绝对值和低CD4/CD8比值是影响中位生存（OS）时间的独立不良预后因素.
结论: 初诊时CD4/CD8比值和CD4+T细胞计数减低是老年MM不良预后因素，T淋巴细胞亚群水平可作为影响临床预后判断的潜在指标.