A comparative assessment of clinical efficiency between premium heat-activated copper nickel-titanium and superelastic nickel-titanium archwires during initial orthodontic alignment in adolescents: a randomized clinical trial

Prog Orthod. 2019 Dec 16;20(1):46. doi: 10.1186/s40510-019-0299-4.


Background: To compare the clinical efficiency of premium heat-activated copper nickel-titanium (Tanzo Cu-NiTi) and NT3 superelastic NiTi during initial orthodontic alignment.

Subject and methods: A total of 50 patients were randomly allocated to 1 of 2 different archwire types (group 1, Tanzo Cu-NiTi; group 2, NT3 superelastic NiTi). Eligibility criteria included Class I or Class II malocclusion, moderate maxillary anterior crowding, and healthy periodontal condition. Impressions of the upper arches were taken before archwire placement (T0) and at every 4 weeks (T1, T2, T3, and T4). For T1 and T2 stages, 0.014-in., and for T3 and T4 stages, 0.018-in. archwires were used. The primary outcome was the alignment efficiency assessed using Little's irregularity index. The secondary outcomes were arch width and incisor inclination changes. Data were analyzed using independent samples t test, repeated measures ANOVA, and Mann-Whitney U test. Marginal models were established for the estimation of coefficients.

Results: The anterior irregularity index reduction was mostly observed between T0 and T2 periods, which were respectively - 7.40 ± 0.50 mm (p < 0.001; 95% CI, - 8.94, - 5.85) and - 6.80 ± 0.55 mm (p < 0.001; 95% CI, - 8.49, - 5.12) for groups 1 and 2 (p < 0.001). With both wires, Little's irregularity index decreased over time, and the difference between the groups was not significant (p = 0.581; estimated effect size, 0.011). No statistically significant difference was found between the groups in terms of intercanine and intermolar width and incisor inclination changes.

Conclusion: There were no significant between-group differences in alignment efficiency, arch width, and incisor inclination change. There was an increased alignment with 0.014-in. compared with 0.018-in. diameter archwire.

Keywords: Alignment; Premium heat-activated Cu-NiTi; Superelastic NiTi.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Copper
  • Dental Alloys
  • Hot Temperature
  • Humans
  • Nickel*
  • Orthodontic Wires
  • Titanium*


  • Dental Alloys
  • Copper
  • Nickel
  • Titanium