Association of variability in antibody binding affinity with a clinical course of anti-MAG neuropathy

J Neuroimmunol. 2020 Feb 15;339:577127. doi: 10.1016/j.jneuroim.2019.577127. Epub 2019 Dec 10.

Abstract

Anti-myelin-associated glycoprotein (MAG) neuropathy is mediated by the binding of IgM M-proteins to the human natural killer-1 epitope of several glycoconjugates, including MAG and phosphacan. We recently reported that IgM M-proteins with a higher ratio of anti-phosphacan titer to anti-MAG titer (P/M ratio) were associated with a progressive clinical course. Herein, we investigated the temporal variability of the P/M ratio. The results showed that P/M ratios in worsened cases were significantly increased relative to stable or improved cases. Thus, temporal variability in the specificity of IgM M-proteins may be related to the disease course of anti-MAG neuropathy.

Keywords: Anti-MAG neuropathy; MAG; P/M ratio; Phosphacan; Prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Autoantibodies / blood*
  • Autoantibodies / immunology
  • Enzyme-Linked Immunosorbent Assay / methods
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoglobulin M / blood
  • Immunoglobulin M / immunology
  • Male
  • Middle Aged
  • Myelin-Associated Glycoprotein / blood*
  • Myelin-Associated Glycoprotein / immunology
  • Peripheral Nervous System Diseases / blood*
  • Peripheral Nervous System Diseases / diagnosis*
  • Peripheral Nervous System Diseases / immunology
  • Protein Binding / physiology

Substances

  • Autoantibodies
  • Immunoglobulin M
  • MAG protein, human
  • Myelin-Associated Glycoprotein