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Enhypyrazinones A and B, Pyrazinone Natural Products From a Marine-Derived Myxobacterium Enhygromyxa Sp

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Enhypyrazinones A and B, Pyrazinone Natural Products From a Marine-Derived Myxobacterium Enhygromyxa Sp

Fan Zhang et al. Mar Drugs.

Abstract

To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wide array of biological activities. Marine-derived myxobacteria are especially attractive due to their unique biosynthetic gene clusters, although they are more difficult to handle than terrestrial myxobacteria. Here, we report the discovery of two new pyrazinone-type molecules, enhypyrazinones A and B, from a marine-derived myxobacterium Enhygromyxa sp. Their structures were elucidated by HRESIMS and comprehensive NMR data analyses. Compounds 1 and 2, which contain a rare trisubstituted-pyrazinone core, represent a unique class of molecules from Enhygromyxa sp.

Keywords: Enhygromyxa sp.; marine-derived myxobacterium; pyrazinone.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Secondary metabolites from Enhygromyxa spp.
Figure 2
Figure 2
Two new pyrazinone derivatives: enhypyrazinones A (1) and B (2).
Figure 3
Figure 3
Extracted ion chromatogram (EIC) traces (m/z 392) of the culture extracts from WMMC2659 (living Escherichia coli DH5α as media) and E. coli DH5α.
Figure 4
Figure 4
Key 2D NMR correlations for compound 1.

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